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El precondicionamiento no atenúa el aturdimiento miocárdico.

M Ovize1, K Przyklenk, S L Hale

  • 1Heart Institute Research, Hospital of the Good Samaritan, Los Angeles, CA 90017.

Circulation
|June 1, 1992
PubMed
Resumen

El acondicionamiento previo del miocardio no protege contra la disfunción contráctil durante la isquemia reversible ni previene el aturdimiento después de la reperfusión. Este estudio no encontró ningún beneficio del precondicionamiento en un modelo canino, lo que desafía los hallazgos anteriores.

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Área de la Ciencia:

  • Cardiología Cardiología.
  • Fisiología cardiovascular fisiología cardiovascular.
  • Enfermedad Isquémica del Corazón Enfermedad Isquémica del Corazón

Sus antecedentes:

  • El acondicionamiento previo del miocardio típicamente reduce el tamaño del infarto después de una isquemia prolongada.
  • Investigaciones anteriores indicaron que el precondicionamiento puede no atenuar la disfunción contráctil en el tejido peri-infarto.
  • Se desconoce el efecto del precondicionamiento en el miocardio no comprometido sometido a isquemia corta.

Objetivo del estudio:

  • Investigar los efectos del precondicionamiento en la función contráctil miocárdica durante la isquemia reversible.
  • Para determinar si el precondicionamiento previene el aturdimiento miocárdico después de un breve insulto isquémico.
  • Para evaluar el impacto del precondicionamiento en el miocardio no comprometido por el régimen de precondicionamiento en sí.

Principales métodos:

  • Utilizó un modelo canino de aturdimiento miocárdico.
  • Se administraron tres grupos de tratamiento: control, oclusión de 5 minutos / reperfusión de 5 minutos (PC5) y oclusión de 2,5 minutos / reperfusión de 5 minutos (PC2.5) antes de un insulto isquémico de 15 minutos.
  • Se monitoreó el acortamiento del segmento (SS) a través de la sonomicrometría y se evaluó el flujo sanguíneo miocárdico utilizando microsferas radiomarcadas.

Principales resultados:

  • Todos los grupos experimentaron niveles de isquemia similares durante la oclusión de 15 minutos.
  • El grupo PC5 mostró un aturdimiento significativo antes del insulto principal, mientras que el PC2.5 no lo hizo.
  • No se observó ninguna diferencia significativa en el acortamiento del segmento durante la isquemia o el grado de aturdimiento después de la reperfusión entre los grupos.

Conclusiones:

  • El precondicionamiento miocárdico no preservó la función contráctil durante la isquemia reversible.
  • El precondicionamiento no impidió el aturdimiento miocárdico en las primeras horas de la reperfusión.
  • La relación entre el flujo sanguíneo colateral y la recuperación funcional no se vio alterada por el precondicionamiento.