Video Experimental Relacionado
Updated: Jul 15, 2026
10:05
Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
Published on: May 24, 2011
Aceleración de la rotación de células epiteliales intestinales: un nuevo mecanismo de expulsión de parásitos
Laura J Cliffe1, Neil E Humphreys, Thomas E Lane
1Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Science (New York, N.Y.)
|June 4, 2005
Resumen
El intestino grueso expulsa gusanos parásitos como Trichuris al aumentar la rotación de células epiteliales, un proceso controlado por señales inmunes. Este mecanismo de "escalera mecánica epitelial" pone de relieve la barrera intestinal.
Área de la Ciencia:
- Inmunología Inmunología.
- Gastroenterología y Gastroenterología.
- Biología celular Biología celular.
Sus antecedentes:
- La barrera epitelial intestinal es crucial para la defensa contra los patógenos.
- Los nematodos gastrointestinales, como el Trichuris, están muy extendidos en todo el mundo.
- Comprender las interacciones huésped-patógeno en la superficie de la mucosa es vital.
Objetivo del estudio:
- Para investigar el papel de la rotación de células epiteliales en la expulsión de nematodos intestinales.
- Identificar los mecanismos inmunológicos que controlan el movimiento de las células epiteliales en el intestino.
Principales métodos:
- Estudió las tasas de rotación de células epiteliales en el intestino grueso.
- Investigó el papel de la citoquina interleucina-13 (IL-13) y la quimioquina CXCL10.
- Modelos utilizados de la infección por Trichuris.
Principales resultados:
- El aumento de la rotación de células epiteliales en el intestino grueso actúa como una "escalera escalonada epitelial" para expulsar Trichuris.
- El movimiento de las células epiteliales está regulado por factores inmunológicos, específicamente IL-13 y CXCL10.
- Este mecanismo representa una importante estrategia de defensa del anfitrión.
Conclusiones:
- La rotación de células epiteliales es un mecanismo activo de defensa del huésped contra los parásitos intestinales.
- Las citoquinas inmunes como la IL-13 y las quimiocinas como la CXCL10 juegan un papel clave en la regulación de esta expulsión.
- El epitelio intestinal tiene un papel multifuncional en la inmunidad de la mucosa.
Más Videos Relacionados
07:42Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
Published on: July 13, 2016
07:32An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
Published on: December 3, 2020
Videos de Conceptos Relacionados
01:35Cancer Cell Migration through Invadopodia
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
01:16Cell Motility through Blebbing
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
01:23Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
01:27Histology of the Small Intestine
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...