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Síntesis de la (-) -tetraciclina

Mark G Charest1, Dionicio R Siegel, Andrew G Myers

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Journal of the American Chemical Society
|June 9, 2005
PubMed
Resumen

Este estudio detalla una síntesis enantioselectiva de 17 pasos de (-) -tetraciclina a partir de ácido benzoico, logrando un rendimiento general del 1,1%. Los pasos clave incluyeron una cicloadición Diels-Alder y una oxidación estereoselectiva para una producción eficiente de antibióticos.

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