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La velocidad de onda elevada del pulso aórtico, un marcador de rigidez arterial, predice eventos cardiovasculares en
Kim Sutton-Tyrrell1, Samer S Najjar, Robert M Boudreau
1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. Tyrrell@edc.pitt.edu
Circulation
|June 22, 2005
Resumen
Una mayor velocidad de onda del pulso aórtico (aPWV), una medida de la rigidez arterial, está relacionada con un aumento de la mortalidad y los eventos cardiovasculares en adultos mayores. Este hallazgo destaca aPWV como un predictor significativo de los resultados de salud en las poblaciones de ancianos que viven en la comunidad.
Área de la Ciencia:
- Medicina cardiovascular La medicina cardiovascular es una especialidad de la medicina cardiovascular.
- Gerontología Gerontología.
- Ingeniería biomédica de la ingeniería biomédica.
Sus antecedentes:
- El envejecimiento se asocia con un aumento de la rigidez vascular y la velocidad de onda del pulso aórtico (aPWV).
- El aPWV elevado está relacionado con la mortalidad en entornos clínicos, pero no se ha estudiado ampliamente en poblaciones generales.
- La rigidez arterial es un indicador clave de la salud cardiovascular en personas mayores.
Objetivo del estudio:
- Investigar la asociación entre aPWV y la mortalidad total en adultos mayores que viven en la comunidad.
- Para determinar si aPWV predice la mortalidad cardiovascular (CV) y los eventos CV.
- Para evaluar el valor pronóstico de aPWV en una población general de ancianos.
Principales métodos:
- La velocidad de onda del pulso aórtico (aPWV) se midió en 2488 participantes del estudio de salud, envejecimiento y composición corporal (Health ABC).
- La mortalidad de los participantes, las causas de muerte y los eventos cardiovasculares (enfermedad coronaria, accidente cerebrovascular, insuficiencia cardíaca) fueron seguidos durante 4,6 años.
- Los análisis estadísticos examinaron la asociación entre los cuartiles de aPWV y los resultados adversos para la salud, con ajustes por covariables.
Principales resultados:
- Los niveles más altos de aPWV se asociaron significativamente con un aumento de la mortalidad total (RR 1.5-1.7) y la mortalidad cardiovascular (RR 2.1-3.0).
- El aumento de aPWV también se relacionó significativamente con una mayor incidencia de enfermedad coronaria (CHD) y accidente cerebrovascular.
- Estas asociaciones persistieron después de ajustar por edad, género, raza, presión arterial y enfermedad cardiovascular preexistente.
Conclusiones:
- La velocidad de onda del pulso aórtico (aPWV) es un marcador significativo de rigidez arterial en adultos mayores.
- El aPWV elevado se asocia de forma independiente con un aumento de la mortalidad cardiovascular, enfermedad coronaria y accidente cerebrovascular en los ancianos que viven en la comunidad.
- aPWV sirve como un valioso predictor de los resultados cardiovasculares adversos en la población general de envejecimiento.
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