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Cortisol, testosterona y enfermedad coronaria: evidencia prospectiva del estudio de Caerphilly
George Davey Smith1, Yoav Ben-Shlomo, Andrew Beswick
1Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, BS8 2PR, UK.
Circulation
|July 13, 2005
Resumen
Una relación elevada de cortisol a testosterona está relacionada con un mayor riesgo de enfermedad cardíaca isquémica, potencialmente mediada por la resistencia a la insulina. Este hallazgo sugiere una conexión entre el equilibrio hormonal y la salud cardiovascular.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Psiconeuroendocrinología psiconeuroendocrinología
Sus antecedentes:
- Se cree popularmente que el estrés crónico causa enfermedades cardíacas a través de vías psiconeuroendocrinas.
- Este estudio investiga la asociación entre la relación cortisol-testosterona y el riesgo de enfermedad cardíaca isquémica.
Objetivo del estudio:
- Para examinar si una elevada proporción de cortisol circulante a la testosterona aumenta el riesgo de enfermedad isquémica del corazón.
Principales métodos:
- Estudio de cohorte prospectivo de 2512 hombres de 45 a 59 años.
- El seguimiento promedio fue de 16,5 años.
- Análisis de muestras de sangre en ayunas matutinas para cortisol, testosterona y factores de riesgo cardiovascular.
Principales resultados:
- La relación cortisol:testosterona mostró fuertes asociaciones positivas con los componentes del síndrome de resistencia a la insulina.
- Se observó una tendencia lineal positiva entre la relación cortisol:testosterona y la enfermedad cardíaca isquémica incidente.
- Esta asociación se atenuó después de ajustar los componentes del síndrome de resistencia a la insulina.
Conclusiones:
- Este es el primer estudio prospectivo basado en la población para encontrar una asociación específica entre la relación cortisol:testosterona y la enfermedad cardíaca isquémica incidente.
- El vínculo parece estar mediado a través del síndrome de resistencia a la insulina.
- Los factores subyacentes (estrés crónico, comportamiento, genética) requieren una mayor investigación.
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