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Updated: May 3, 2026

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
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Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry

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Conocimiento estructural sobre la biosíntesis del antibiótico fosfomicina por una enzima de hierro mononuclear

Luke J Higgins1, Feng Yan, Pinghua Liu

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature
|July 15, 2005
PubMed
Resumen

Los conocimientos estructurales revelan que la epoxidasa de ácido hidroxipropilfosfónico, una nueva enzima en la biosíntesis de la fosfomicina, utiliza mecanismos únicos para el reconocimiento y la catálisis del sustrato. Este estudio aclara su función como una nueva subfamilia de enzimas de hierro mononucleares no hemo.

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