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Orientación de la proteína precursora beta-amiloide de la superficie celular hacia los lisosomas: procesamiento

C Haass1, E H Koo, A Mellon

  • 1Department of Neurology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.

Nature
|June 11, 1992
PubMed
Resumen

La enfermedad de Alzheimer implica la acumulación de péptido beta amiloide. Este estudio revela una segunda vía para el procesamiento de la proteína precursora beta-amiloide (beta APP) en los lisosomas, generando potencialmente fragmentos de amiloide relacionados con la enfermedad de Alzheimer.

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