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Updated: Jul 16, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Estudio computacional de la actividad de la fosfatasa en la hidrolasa de epóxido soluble: alta eficiencia a través de

Marco De Vivo1, Bernd Ensing, Michael L Klein

  • 1Center for Molecular Modeling, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA. mdevivo@cmm.upenn.edu

Journal of the American Chemical Society
|August 11, 2005
PubMed
Resumen

La hidrolasa de epoxido soluble (sEH) exhibe una nueva actividad de la fosfatasa, revelando un nuevo objetivo para el desarrollo de fármacos. Los estudios computacionales aclararon un mecanismo de reacción concertado, incluido un puente de agua crucial para la catálisis.

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