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Desentrañar la replicación del virus de la hepatitis C del genoma para que funcione

Brett D Lindenbach¹, Charles M Rice

¹Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

|August 19, 2005

Resumen

Los científicos han progresado en la comprensión del virus de la hepatitis C (VHC) a pesar de los desafíos. Nuevas terapias antivirales para el VHC están ahora en ensayos clínicos, ofreciendo esperanza para el tratamiento.

Área de la Ciencia:

Virología Virología.
Hepatología Hepatología.
Enfermedades infecciosas Enfermedades infecciosas.

Sus antecedentes:

El descubrimiento del virus de la hepatitis C (VHC) hace más de 15 años inició la investigación en el diagnóstico, la patogénesis y la terapéutica.
La investigación se enfrentó a obstáculos significativos debido a la limitada gama de huéspedes para la replicación (humanos / chimpancés) y la falta de modelos eficientes de cultivo celular.

Objetivo del estudio:

Para resumir los progresos realizados en la comprensión y la lucha contra el virus de la hepatitis C.
Para resaltar el desarrollo de nuevas terapias antivirales para el VHC.

Principales métodos:

Revisión de la literatura científica sobre la investigación del virus de la hepatitis C.
Análisis de los desafíos en la replicación del VHC y el desarrollo de fármacos.

Principales resultados:

A pesar de las dificultades iniciales, se han logrado avances significativos en la investigación del VHC.
La primera generación de medicamentos antivirales dirigidos al VHC ha progresado con éxito a los ensayos clínicos.

Conclusiones:

Se han logrado progresos duros en la investigación del virus de la hepatitis C y el desarrollo de terapias.
Los fármacos antivirales emergentes representan un importante paso adelante en el manejo de las infecciones por el VHC.

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