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La inhibición de la ARN polimerasa por la estreptolidigina: no se permite el ciclo

Scotty Kyzer1, Jinwei Zhang, Robert Landick

  • 1Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Cell
|August 27, 2005
PubMed
Resumen

El antibiótico estreptolidigina inhibe la ARN polimerasa bacteriana al bloquear los movimientos clave en el sitio activo de la enzima. Esta visión estructural revela cómo la estreptolidigina interrumpe la transcripción bacteriana, ofreciendo potencial para el desarrollo de nuevos antibióticos.

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