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DNA Vector-based RNA Interference to Study Gene Function in Cancer
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La genómica funcional del ARN no codificante.

John S Mattick1

  • 1Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia. j.mattick@imb.uq.edu.au

Science (New York, N.Y.)
|September 6, 2005
PubMed
Resumen

Los investigadores desarrollaron un nuevo método para la detección de ARN no codificantes (ARNnc). Este enfoque identificó un ncRNA que reprime el factor de transcripción NFAT, revelando una nueva capa de regulación génica.

Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • Regulación genética Reglamento genético.

Sus antecedentes:

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  • Los avances recientes en la clonación de ADNc y las matrices de tiling del genoma han revelado numerosas transcripciones de ARN no codificantes (ARNnc) en animales.
  • Una pregunta clave en el campo es determinar la relevancia funcional de estos ncRNAs.