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Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
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CNS Stimulants: Psychedelic Agents

Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain that...
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Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
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Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Video Experimental Relacionado

Updated: Jun 30, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
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Published on: May 18, 2020

Llevando el LSD 1 a un nuevo nivel.

Joanna Wysocka1, Thomas A Milne, C David Allis

  • 1Laboratory of Chromatin Biology, the Rockerfeller University, New York, NY 10021, USA.

Cell
|September 7, 2005
PubMed
Resumen

La histona desmetilasa LSD1 es también conocida como LSD1.

Área de la Ciencia:

  • Epigenética y regulación génica.
  • Biología molecular La biología molecular.
  • La bioquímica es la bioquímica.

Sus antecedentes:

  • La metilación de la histona es una modificación epigenética clave que regula la expresión génica.
  • La histona desmetilasa LSD1 (desmetilasa específica de lisina 1) fue descubierta recientemente, desafiando la noción de metilación irreversible de la histona.
  • Se estableció el papel de LSD1 en la desmetilación de la histona H3 lisina 4 (H3K4).

Objetivo del estudio:

  • Investigar los mecanismos regulatorios que rigen la especificidad y la actividad de LSD1.
  • Para identificar los cofactores de proteínas que modulan la función de LSD1.
  • Comprender las implicaciones más amplias para la regulación epigenética de los genes.

Principales métodos:

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  • Pruebas bioquímicas para evaluar la actividad de la LSD1 demetilasa.
  • Co-inmunoprecipitación para identificar las proteínas que interactúan.
  • Análisis de cambios en la expresión génica en respuesta a la modulación del cofactor LSD1.

    • Principales resultados:

    • La especificidad y la actividad de la desmetilasa de LSD1 están reguladas por cofactores de proteínas asociados.
    • Cofactores específicos mejoran o inhiben la capacidad de LSD1 para desmetilación de la histona H3.
    • Estas interacciones son cruciales para el control preciso de la expresión génica.

    Conclusiones:

    • La función de LSD1 no depende únicamente de la enzima en sí misma, sino que está modulada por una compleja red de cofactores de proteínas.
    • Comprender estas interacciones de cofactores proporciona una visión más matizada de la regulación epigenética.
    • Esta investigación abre nuevas vías para dirigirse a los mecanismos epigenéticos en el tratamiento de enfermedades.