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Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
Published on: March 16, 2018
La adhesión específica por etapas de Leishmania promastigotes a la mosca de arena del intestino medio promueve la
P F Pimenta1, S J Turco, M J McConville
1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Science (New York, N.Y.)
|June 26, 1992
Resumen
Los parásitos de Leishmania se adhieren a los intestinos internos de las moscas de arena a través de los azúcares superficiales. Este apego se pierde durante el desarrollo, permitiendo que los parásitos infecciosos sean liberados para la transmisión a los humanos.
Área de la Ciencia:
- Biología vectorial Biología vectorial.
- Parasitología Parasitología.
- Biología molecular La biología molecular.
Sus antecedentes:
- La transmisión de la leishmaniasis se basa en vectores de mosca de arena, pero las interacciones parásito-vector son poco conocidas.
- La supervivencia y el desarrollo de los parásitos Leishmania dentro de las moscas de arena son fundamentales para la transmisión de enfermedades.
Objetivo del estudio:
- Investigar los mecanismos moleculares que controlan la adhesión y liberación del parásito Leishmania en el vector de la mosca de arena.
- Identificar las moléculas parásitas involucradas en la regulación de las etapas de desarrollo dentro del insecto huésped.
Principales métodos:
- Estudió las propiedades de adhesión de Leishmania promastigotes a las células epiteliales del intestino medio de la mosca de arena.
- Se analizaron los cambios en el desarrollo de las moléculas de la superficie del parásito, específicamente el lipofosfoglicano (LPG).
- Investigó el papel de los sacáridos terminales en el GLP en la fijación y liberación de parásitos.
Principales resultados:
- Las promastigotas de Leishmania exhiben una adhesión inherente a las células del intestino medio de la mosca de arena.
- Esta propiedad de adhesión se pierde durante la transformación a formas metacíclicas infecciosas.
- Las modificaciones en el desarrollo de los sacáridos terminales en el lipofosfoglicano controlan la fijación y liberación del intestino medio.
Conclusiones:
- El lipofosfoglicano (LPG) y sus sacarídeos superficiales son reguladores clave del desarrollo y la transmisión de Leishmania dentro de las moscas de arena.
- La comprensión de estas interacciones puede informar estrategias para controlar la transmisión de la leishmaniasis.
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