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Mejora de la sensibilidad en experimentos de cribado basados en RMN de 19F: consideraciones teóricas y aplicaciones

Claudio Dalvit1, Nicola Mongelli, Gianluca Papeo

  • 1Chemistry Department, Nerviano Medical Sciences, 20014 Nerviano, Milano, Italy. claudio.dalvit@nervianoms.com

Journal of the American Chemical Society
|September 22, 2005
PubMed
Resumen

Una nueva sonda criogénica de flúor-19 mejora la detección basada en RMN (FAXS y 3-FABS) para el descubrimiento de fármacos. Esto mejora la sensibilidad, lo que permite un mayor rendimiento y la detección de aglutinantes más débiles y más lentos con necesidades de muestras reducidas.

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