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Los murciélagos son reservorios naturales de los coronavirus parecidos al SARS
Wendong Li1, Zhengli Shi, Meng Yu
1Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China.
Science (New York, N.Y.)
|October 1, 2005
Resumen
Los murciélagos son huéspedes naturales de los coronavirus similares al SARS (SL-CoV), que están estrechamente relacionados con el coronavirus SARS (SARS-CoV). Las cepas humanas y de civeta del SARS-CoV forman parte del diverso grupo SL-CoV que se encuentra en los murciélagos.
Área de la Ciencia:
- Virología Virología.
- Enfermedades zoonóticas Las enfermedades zoonóticas son enfermedades zoonóticas.
- Epidemiología La epidemiología.
Sus antecedentes:
- El Síndrome Respiratorio Agudo Severo (SARS) surgió en 2002-2003, sin que se conozca su origen preciso.
- El agente etiológico, el coronavirus SARS (SARS-CoV), ha sido identificado, pero su reservorio natural no se ha establecido definitivamente.
Objetivo del estudio:
- Investigar el reservorio natural y el origen del coronavirus SARS (SARS-CoV).
- Para identificar potenciales huéspedes animales que albergan coronavirus relacionados con el virus del brote de SARS.
Principales métodos:
- Análisis filogenético de las secuencias genéticas del coronavirus.
- Comparación de la variación genética viral entre los aislamientos de murciélagos, civetas y humanos.
Principales resultados:
- Se identificaron coronavirus estrechamente relacionados con el SARS-CoV en especies de murciélagos.
- Estos virus derivados de murciélagos, denominados coronavirus similares al SARS (SL-CoVs), exhibieron una mayor diversidad genética que el SARS-CoV humano o de civeta.
- Los aislamientos de SARS-CoV humanos y de civetas estaban filogenéticamente anidados dentro del grupo más amplio de SL-CoV.
Conclusiones:
- Los murciélagos sirven como un reservorio natural para los coronavirus estrechamente relacionados con el virus del brote de SARS.
- El virus del brote de SARS probablemente se originó en este diverso grupo de coronavirus asociados con murciélagos.
- Comprender los coronavirus del murciélago es crucial para prevenir la aparición futura de enfermedades zoonóticas.
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