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Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

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Updated: Jul 5, 2026

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

El colangiocarcinoma es un cáncer de colangiocarcinoma.

Shahid A Khan1, Howard C Thomas, Brian R Davidson

  • 1Liver Unit, Division of Medicine, St Mary's Hospital Campus, Faculty of Medicine, Imperial College London, London, UK. shahid.khan@imperial.ac.uk

Lancet (London, England)
|October 11, 2005
PubMed
Resumen
Este resumen es generado por máquina.

El colangiocarcinoma, un cáncer del conducto biliar, se diagnostica cada vez más tarde con malos resultados. Si bien la resección quirúrgica ofrece la única cura, el trasplante de hígado y el drenaje biliar paliativo son opciones para casos avanzados.

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Área de la Ciencia:

  • La medicina hepática y biliar.
  • Oncología Quirúrgica Oncología Quirúrgica.
  • Gastroenterología y Gastroenterología.

Sus antecedentes:

  • El colangiocarcinoma (cáncer del conducto biliar) es una malignidad grave con presentación tardía, desafíos de diagnóstico y alta mortalidad.
  • La incidencia del colangiocarcinoma intrahepático está aumentando a nivel mundial, posiblemente debido a factores genéticos y ambientales.
  • Las herramientas de diagnóstico actuales incluyen resonancia magnética, tomografía computarizada, ecografía endoscópica y PET, que proporcionan información valiosa en pacientes seleccionados.

Objetivo del estudio:

  • Para resumir la comprensión actual y el manejo del colangiocarcinoma.
  • Para resaltar las modalidades de diagnóstico y las estrategias de tratamiento para el colangiocarcinoma intrahepático.
  • Para discutir las opciones de cuidados paliativos para el cáncer de conducto biliar no resecable.

Principales métodos:

  • Revisión de la literatura existente sobre el diagnóstico y tratamiento del colangiocarcinoma.
  • Análisis de las técnicas de imagen (IRM, TC, EUS, PET) para su utilidad diagnóstica.
  • Evaluación de la resección quirúrgica, el trasplante de hígado, la quimioterapia, la radioterapia y las intervenciones paliativas.

Principales resultados:

  • La resección quirúrgica sigue siendo la única opción curativa, dependiendo de la técnica y la selección del paciente.
  • El trasplante de hígado, con quimioradioterapia neoadyuvante, es prometedor para la supervivencia a largo plazo en pacientes seleccionados.
  • La quimioterapia y la radioterapia son en gran medida ineficaces para los tumores inoperables; el drenaje biliar es clave para la paliación.

Conclusiones:

  • El manejo del colangiocarcinoma requiere un enfoque multidisciplinario, equilibrando las estrategias curativas y paliativas.
  • El diagnóstico precoz y la selección del paciente son fundamentales para mejorar los resultados en el cáncer de conducto biliar.
  • Las nuevas técnicas paliativas como la terapia fotodinámica pueden mejorar la calidad de vida de los casos avanzados.