Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Pedigree Analysis01:35

Pedigree Analysis

Overview
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes.

Diabetes care·2024
Same author

Widening the phenotypic spectrum caused by pathogenic <i>PDX1</i> variants in individuals with neonatal diabetes.

BMJ open diabetes research & care·2024
Same author

The impact of prolonged walking on fasting plasma glucose in type 2 diabetes: A randomised controlled crossover study.

Diabetic medicine : a journal of the British Diabetic Association·2024
Same author

A homozygous TARS2 variant is a novel cause of syndromic neonatal diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2024
Same author

Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Glibenclamide in a Young Adult With KCNJ11 Permanent Neonatal Diabetes.

Diabetes care·2024
Same author

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.

Wellcome open research·2024

Video Experimental Relacionado

Updated: Jul 18, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

¿Qué hace un buen estudio de asociación genética?

Andrew T Hattersley1, Mark I McCarthy

  • 1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK.

Lancet (London, England)
|October 11, 2005
PubMed
Resumen

Replicar los hallazgos de asociación genética para enfermedades complejas es un desafío debido a los defectos del diseño del estudio, particularmente muestras con poca potencia. Centrarse en la calidad del estudio sobre la mera importancia es crucial para obtener resultados confiables.

Más Videos Relacionados

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Videos de Experimentos Relacionados

Last Updated: Jul 18, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Área de la Ciencia:

  • Genética La genética.
  • Epidemiología Genómica y Genómica.
  • La bioestadística es la bioestadística.

Sus antecedentes:

  • Los estudios de asociación genética tienen como objetivo identificar variantes genómicas vinculadas a enfermedades multifactoriales.
  • La replicación de los hallazgos iniciales en los estudios de asociación genética a menudo es difícil, lo que dificulta el progreso.

Objetivo del estudio:

  • Para resaltar los factores críticos que influyen en la robustez y la reproducibilidad de los estudios de asociación genética.
  • Para enfatizar la importancia de la calidad del estudio en la interpretación de los hallazgos de asociación genética.

Principales métodos:

  • El resumen analiza las trampas comunes en el diseño, la implementación y la interpretación del estudio de asociación genética.
  • Enfatiza la necesidad de poder estadístico adecuado, reclutamiento de muestras apropiado, selección de variantes lógicas, errores de genotipado minimizados y análisis de datos sólidos.

Principales resultados:

  • Las inconsistencias en los hallazgos de asociación genética se deben con frecuencia a insuficiencias metodológicas, especialmente tamaños de muestra insuficientes.
  • Los hallazgos robustos dependen de una combinación de factores que incluyen el diseño, la ejecución y el análisis del estudio.

Conclusiones:

  • La replicación es esencial para distinguir las verdaderas asociaciones biológicas de los artefactos metodológicos.
  • La calidad del estudio, más que la significación estadística, debe ser el principal determinante para evaluar la evidencia en los estudios de asociación genética.