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Rediseño de la enzima: dos mutaciones cooperan para convertir la cicloartenol sintasa en una precisa lanosterol

Silvia Lodeiro1, Tanja Schulz-Gasch, Seiichi P T Matsuda

  • 1Department of Chemistry and Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA.

Journal of the American Chemical Society
|October 13, 2005
PubMed
Resumen

Los investigadores diseñaron la cicloartenol sintasa en una sintasa de lanosterol altamente específica. Este rediseño de la enzima logró una precisión del 99% en la producción de lanosterol mediante la combinación de polaridad y modificaciones estéricas.

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