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Potentes inhibidores selectivos basados en pironas de la estromelisina-1

David T Puerta1, John Mongan, Ba L Tran

  • 1Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, and Center for Theoretical Biological Physics, University of California-San Diego, La Jolla, CA 92093, USA.

Journal of the American Chemical Society
|October 13, 2005
PubMed
Resumen

Los investigadores desarrollaron nuevos inhibidores de la metaloproteinasa de matriz (IMP) basados en pirona como alternativas a los compuestos de hidroxamato. Estos inhibidores muestran una alta potencia y selectividad para MMP-3, ofreciendo una nueva clase prometedora de fármacos candidatos.

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