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Los genes Hox: los instructores que trabajan en las piscinas de motor
Mi-Ryoung Song1, Samuel L Pfaff
1Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA.
Cell
|November 5, 2005
Resumen
Los genes Hox instruyen el desarrollo del grupo motor en la médula espinal. Esta investigación aclara cómo las neuronas motoras adquieren identidades únicas para la inervación muscular precisa.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología del desarrollo Biología del desarrollo.
- Genética La genética.
Sus antecedentes:
- Las neuronas motoras requieren identidades específicas para la orientación precisa de los axones y la inervación muscular.
- Los cuerpos celulares de las neuronas motoras forman grupos distintos llamados piscinas motoras en la médula espinal.
- Los mecanismos moleculares subyacentes a la diversificación de las neuronas motoras seguían siendo en gran medida desconocidos.
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00:46Motor Units
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02:33Combinatorial Gene Control
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The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
02:23Master Transcription Regulators
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01:13Motor Units
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
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01:18Hierarchy of Motor Control
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.