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Videos de Conceptos Relacionados

Endoplasmic Reticulum01:39

Endoplasmic Reticulum

119.3K
The Endoplasmic Reticulum (ER) in eukaryotic cells is a substantial network of interconnected membranes with diverse functions, from calcium storage to biomolecule synthesis. A primary component of the endomembrane system, the ER manufactures phospholipids critical for membrane function throughout the cell. Additionally, the two distinct regions of the ER specialize in the manufacture of specific lipids and proteins.
119.3K
Golgi Apparatus01:49

Golgi Apparatus

108.0K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
108.0K
Golgi Apparatus01:09

Golgi Apparatus

22.7K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
22.7K
The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

22.7K
The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
22.7K
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

8.8K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
8.8K
The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

3.6K
No description available
3.6K

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bioRxiv : the preprint server for biology·2026
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Septins associate with AP-3 to support trafficking to the vacuole/lysosome in yeast.

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Hoi1 targets BLTP2 to ER-PM contact sites to regulate lipid homeostasis.

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Septins associate with AP-3 to support trafficking to the vacuole/lysosome in yeast.

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The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins.

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Video Experimental Relacionado

Updated: Apr 2, 2026

Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells
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Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells

Published on: February 18, 2014

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Un E-MAP del ER para el ER.

Elizabeth Conibear1

  • 1Center for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver V5Z 4H4, Canada.

Cell
|November 5, 2005
PubMed
Resumen

El análisis de epistasis de saturación revela relaciones genéticas funcionales. Esta estrategia de datos genómicos de alto rendimiento descubre la función génica en la vía secretora de la levadura.

Área de la Ciencia:

  • La genómica es la genómica.
  • Biología de Sistemas Biología de Sistemas.
  • Biología Molecular Biología Molecular

Sus antecedentes:

  • El mapeo del fenotipo de todo el genoma ofrece información sobre la función del gen.
  • Comprender las interacciones genéticas es crucial para la investigación biológica.

Objetivo del estudio:

  • Desarrollar una nueva estrategia para descubrir las relaciones funcionales entre los genes.
  • Aplicar el análisis de datos genómicos de alto rendimiento a la genética de la levadura.

Principales métodos:

  • Análisis de epistasis de la saturación.
  • Análisis de genes en la vía secretora temprana de la levadura.
  • Utilización de datos genómicos de alto rendimiento.

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Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart
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Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart

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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

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Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart
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Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart

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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

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Principales resultados:

  • Se demostró una nueva estrategia para descubrir las relaciones genéticas funcionales.
  • El estudio aplicó con éxito el análisis de epistasis de saturación a la genética de la levadura.
  • Se aclararon las relaciones funcionales dentro de la vía secretora temprana.

Conclusiones:

  • El análisis de epistasis de saturación es una poderosa estrategia para la genómica funcional.
  • Los datos de alto rendimiento se pueden utilizar de manera efectiva para mapear la función génica.
  • Este enfoque proporciona un nuevo marco para la comprensión de vías biológicas complejas.