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Las muchas caras de PPARgamma

Michael Lehrke¹, Mitchell A Lazar

¹Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

|December 20, 2005

Resumen

El receptor gamma activado por el proliferador de peroxisomas (PPARgamma) regula el metabolismo y el almacenamiento de grasa, contribuyendo a la obesidad pero también sirviendo como objetivo para los medicamentos para la diabetes. La modulación selectiva de PPARgamma puede ofrecer beneficios terapéuticos con efectos secundarios reducidos.

Área de la Ciencia:

Biología molecular La biología molecular.
Las enfermedades metabólicas son enfermedades metabólicas.
Los receptores nucleares se encuentran en los receptores nucleares.

Sus antecedentes:

La obesidad, la diabetes y las enfermedades cardiovasculares son problemas de salud prevalentes en todo el mundo.
El receptor gamma activado por el proliferador peroxisomático (PPARgamma) es un regulador transcripcional clave del metabolismo.
El papel de PPARgamma en la acumulación de tejido adiposo lo vincula con la obesidad.

Objetivo del estudio:

Para explorar el potencial terapéutico de la orientación PPARgamma.
Para investigar la modulación selectiva de la actividad de PPARgamma.
Para reducir los efectos secundarios asociados con los ligandos PPARgamma actuales.

Principales métodos:

Análisis de la biología básica de PPARgamma.
Investigando moduladores de moléculas pequeñas de PPARgamma.
Explorando estrategias de modulación específicas del tejido y del gen objetivo.

Principales resultados:

Los ligandos PPARgamma son fármacos antidiabéticos muy efectivos.
Las terapias PPARgamma actuales tienen efectos secundarios limitados.
La orientación selectiva puede mejorar el beneficio terapéutico y la seguridad.

Conclusiones:

PPARgamma es un regulador crítico del metabolismo de las grasas.
La modulación selectiva de PPARgamma ofrece una vía terapéutica prometedora.
Se justifica una mayor investigación sobre la orientación PPARgamma específica del tejido.

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