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Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana
Published on: May 29, 2010
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La organización de la cromatina y el interruptor del destino celular responden a la información posicional en la
1Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.
Nature
|December 20, 2005
Resumen
Las células vegetales pueden cambiar el destino en función de su posición. En las raíces de Arabidopsis, la organización de la cromatina alrededor del gen GLABRA2 (GL2) se restablece durante la división celular, lo que permite cambios en el destino celular y plasticidad del desarrollo.
Área de la Ciencia:
- Biología del desarrollo vegetal Biología del desarrollo vegetal
- La plasticidad celular es la plasticidad celular.
- La epigenética es la epigenética.
Sus antecedentes:
- Las células vegetales exhiben plasticidad del desarrollo, capaces de cambiar de destino cuando cambian las señales ambientales.
- En las raíces de Arabidopsis, las células epidérmicas se diferencian en células ciliadas y no ciliadas en función de la información de posición y la actividad del factor de transcripción GLABRA2 (GL2).
Objetivo del estudio:
- Para investigar el papel de la organización de la cromatina en la especificación del tipo de célula dependiente de la posición en la raíz de Arabidopsis epidermis.
- Comprender cómo ocurren los cambios en el destino celular cuando las células se desplazan a nuevos entornos posicionales.
Principales métodos:
- Fluorescencia tridimensional en hibridación in situ (3D FISH) en el tejido epidermal intacto de la raíz de Arabidopsis.
- Análisis de la organización de la cromatina alrededor del locus GLABRA2 (GL2).
- Seguimiento de los cambios en el destino celular después de las divisiones celulares atípicas.
Principales resultados:
- Los estados alternativos de organización de la cromatina alrededor del locus GL2 son cruciales para controlar la especificación del tipo celular.
- Cuando una célula se desplaza a un nuevo archivo, su estado de cromatina alrededor de GL2 no se hereda, sino que se reorganiza.
- La remodelación de la cromatina ocurre durante la fase G1 del ciclo celular en respuesta a la información posicional local.
Conclusiones:
- La remodelación de la cromatina alrededor del locus GL2 es un mecanismo clave que subyace a la plasticidad del destino celular en la epidermis de la raíz de Arabidopsis.
- La capacidad de las células vegetales para alterar dinámicamente la organización de la cromatina apoya su capacidad de plasticidad del desarrollo.
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