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Aumento de la sensibilidad de los quimiorreceptores periféricos y el ejercicio de la ventilación en los receptores de
Agnieszka Ciarka1, Nicolas Cuylits, Jean-Luc Vachiery
1Department of Cardiology, Erasme University Hospital, 1070 Brussels, Belgium. Agnieszka.Ciarka@ulb.ac.be
Circulation
|January 13, 2006
Resumen
Los receptores de trasplante de corazón muestran una mayor sensibilidad a los quimiorreceptores periféricos, lo que influye en su respuesta respiratoria durante el ejercicio. Este aumento de la sensibilidad está relacionado con la hiperpnea por ejercicio después del trasplante.
Área de la Ciencia:
- Cardiología Cardiología.
- Fisiología de las vías respiratorias.
- Medicina del trasplante Medicina del trasplante.
Sus antecedentes:
- La insuficiencia cardíaca aumenta la ventilación durante el ejercicio debido a una mayor sensibilidad de los quimiorreceptores.
- El trasplante de corazón no normaliza la respuesta ventilatoria al ejercicio, dejando desconocidos los efectos del control de quimiorreflejo.
Objetivo del estudio:
- Para probar si la sensibilidad a los quimiorreceptores está elevada en los receptores de trasplante de corazón (HTR).
- Para determinar si esta sensibilidad elevada está relacionada con el ejercicio hiperpnea.
Principales métodos:
- Evaluó la actividad respiratoria, nerviosa simpática y las respuestas circulatorias a la hipoxia e hipercapnia en HTR y controles.
- Respuestas comparadas a la hipoxia isocápnica y a la hipercapnia hiperóxica.
- Evaluación de la respuesta ventilatoria al ejercicio utilizando ergometría de ciclo.
Principales resultados:
- Los HTR exhibieron una mayor actividad muscular del nervio simpático y la frecuencia cardíaca en reposo en comparación con los controles.
- La respuesta ventilatoria a la hipoxia fue significativamente mayor en los HTR.
- La ventilación por ejercicio fue más pronunciada en los HTR y se correlacionó con sus respuestas respiratorias hipoxicas e hipercapnicas.
Conclusiones:
- La sensibilidad de los quimiorreceptores periféricos aumenta en los receptores de trasplante de corazón.
- Esta mayor sensibilidad se asocia con la hiperpnea por ejercicio después de un trasplante de corazón.
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