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Videos de Conceptos Relacionados

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Video Experimental Relacionado

Updated: May 12, 2026

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects
08:48

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

Published on: February 17, 2016

La actividad nerviosa en un nicho de células madre.

Jonas Larsson1, David Scadden

  • 1Center for Regenerative Medicine, Massachusetts General Hospital, Boston, 02114, USA.

Cell
|January 28, 2006
PubMed
Resumen

El sistema nervioso regula la movilización de las células madre hematopoyéticas mediante la vinculación de las células óseas y nerviosas. Este descubrimiento revela cómo el sistema nervioso influye en los nichos de células madre.

Área de la Ciencia:

  • Hematología Hematología.
  • La neurociencia es la neurociencia.
  • Biología de las células madre Biología de las células madre

Sus antecedentes:

  • Las células madre hematopoyéticas (HSC) son cruciales para la formación de sangre y la función inmune.
  • La movilización de HSC es un proceso complejo influenciado por varios factores sistémicos.
  • El microambiente, o nicho, juega un papel crítico en la regulación de HSC.

Objetivo del estudio:

  • Identificar nuevos mecanismos reguladores que gobiernan la movilización de las células madre hematopoyéticas.
  • Explorar el papel potencial del sistema nervioso en la regulación del nicho de HSC.
  • Para dilucidar la interacción entre el sistema nervioso, el hueso y los HSCs.

Principales métodos:

  • Investigó un eje regulatorio recientemente identificado.

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Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects
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  • Utilizó técnicas avanzadas de imagen y biología molecular.
  • Analizó la interacción entre los componentes del sistema nervioso, el hueso y los HSC.

    • Principales resultados:

    • Se descubrió un nuevo eje regulador que vincula las células madre hematopoyéticas con el sistema nervioso y el hueso.
    • El sistema nervioso parece desempeñar un papel inesperado en el gobierno de los HSC dentro de sus nichos.
    • Este eje proporciona una nueva perspectiva sobre cómo la información sistémica influye en el comportamiento de las células madre locales.

    Conclusiones:

    • El sistema nervioso participa activamente en la regulación del nicho de las células madre hematopoyéticas.
    • Esta interacción entre el sistema nervioso y la médula ósea ofrece nuevos objetivos terapéuticos para los trastornos de la sangre.
    • La investigación futura debe centrarse en los mecanismos moleculares precisos de este eje regulador.