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Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
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Reparación de la ruptura de la doble hebra del ADN: una búsqueda implacable descubre nuevas presas

JoAnn M Sekiguchi1, David O Ferguson

  • 1Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, 48109, USA

Cell
|January 28, 2006
PubMed
Resumen

Los científicos descubrieron Cernunnos-XLF, una nueva proteína crucial para la reparación de la ruptura de la doble cadena de ADN a través de la unión final no homóloga (NHEJ). Las mutaciones en este gen causan un síndrome raro con inmunodeficiencia y problemas de desarrollo.

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