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Factor de tejido en enfermedades cardiovasculares: mecanismos moleculares e implicaciones clínicas
Jan Steffel1, Thomas F Lüscher, Felix C Tanner
1Cardiovascular Research, Physiology Institute, Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
Circulation
|February 8, 2006
Resumen
El factor de tejido (TF) inicia la coagulación de la sangre y está relacionado con enfermedades cardiovasculares. La inhibición de la TF ofrece una estrategia terapéutica prometedora para el tratamiento de estas afecciones.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Biología Vascular Biología Vascular
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
Sus antecedentes:
- El factor de tejido (TF) es el principal iniciador de la cascada de coagulación, vinculando el factor VIIa para activar los factores IX y X, lo que lleva a la formación de fibrina.
- La expresión de TF es inducible en las células endoteliales, las células del músculo liso y los monocitos por diversos estímulos a través de vías de señalización como las quinasas MAP y la PI3-quinasa.
- El TF celular existe en piscinas superficiales, encriptadas e intracelulares, con TF circulante también detectable en el torrente sanguíneo.
Objetivo del estudio:
- Revisar el papel del factor tisular (TF) en la coagulación y la patogénesis de las enfermedades cardiovasculares.
- Explorar los mecanismos de señalización y los grupos celulares de TF.
- Discutir estrategias terapéuticas dirigidas a TF para el tratamiento de enfermedades cardiovasculares.
Principales métodos:
- Revisión de la literatura sobre el papel de la TF en la coagulación y las enfermedades cardiovasculares.
- Análisis de la expresión, actividad y vías de señalización de TF.
- Examen de las intervenciones terapéuticas dirigidas a TF.
Principales resultados:
- Los niveles elevados de TF están asociados con factores de riesgo cardiovascular (hipertensión, diabetes, dislipidemia, tabaquismo) y síndromes coronarios agudos.
- La TF contribuye a la aterosclerosis promoviendo la formación de trombos y la migración/proliferación de células del músculo liso vascular.
- Las estrategias terapéuticas incluyen anticuerpos anti-TF, factor VIIa modificado e inhibidor de la vía TF.
Conclusiones:
- TF es un iniciador crítico de la coagulación y un factor significativo en la patogénesis de enfermedades cardiovasculares.
- La acción dirigida a TF representa una vía terapéutica prometedora para las enfermedades cardiovasculares.
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