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Inflamación y receptores de esteroides sexuales: un motivo para el cambio
Jan J Brosens1, Eric W-F Lam, Malcolm G Parker
1Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London W12 ONN, United Kingdom.
Cell
|February 14, 2006
Resumen
Las señales proinflamatorias activan los receptores de la hormona esteroide reprimida apuntando a TAB2, una proteína que se une a los corepresores. Este descubrimiento ofrece nuevas estrategias para el tratamiento de cánceres resistentes al sistema endocrino.
Área de la Ciencia:
- Biología de la reproducción Biología reproductiva.
- La endocrinología molecular.
- Investigación de la inflamación en la investigación de la inflamación.
Sus antecedentes:
- La homeostasis en los tejidos reproductivos depende de la integración de las señales hormonales e inflamatorias.
- Los receptores de la hormona esteroide juegan un papel crítico en la salud reproductiva y las enfermedades.
- Comprender cómo interactúan estas señales es clave para abordar las patologías relacionadas con el sistema endocrino.
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01:07Types of Receptors: Internal Receptors
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01:26Signal Transduction: Overview
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01:31Transducer Mechanism: Nuclear Receptors
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01:28Inflammatory Response
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