Video Experimental Relacionado
Updated: May 7, 2026
09:32
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
Published on: June 15, 2017
La señalización TOR en el crecimiento y el metabolismo
Stephan Wullschleger1, Robbie Loewith, Michael N Hall
1Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Cell
|February 14, 2006
Resumen
El objetivo de la rapamicina (TOR) regula el crecimiento celular y el metabolismo. La inhibición de la TOR en mamíferos puede tratar el cáncer, las enfermedades cardiovasculares, autoinmunes y metabólicas.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El objetivo de la rapamicina (TOR) es una quinasa Ser/Thr crucial conservada en todas las especies.
- La señalización TOR integra señales ambientales para controlar el crecimiento celular y el metabolismo.
- El TOR de los mamíferos funciona dentro de dos complejos multiproteicos distintos: TORC1 y TORC2.
Objetivo del estudio:
- Revisar el objetivo en mamíferos de los complejos de rapamicina (mTOR).
- Para dilucidar las vías de señalización mediadas por mTOR.
- Para resaltar el potencial terapéutico de los inhibidores de mTOR.
Principales métodos:
- Revisión de la literatura existente y estudios de organismos modelo.
- Análisis de la estructura y función de mTORC1 y mTORC2.2.
- Examen de los resultados fisiológicos de la desregulación de mTORC1.
Principales resultados:
- mTOR existe en dos complejos distintos: TORC1 sensible a la rapamicina y TORC2 insensible a la rapamicina.
- El TORC1 y el TORC2 regulan diferentes procesos celulares.
- La desregulación del TORC1 de los mamíferos está implicada en varias enfermedades.
Conclusiones:
- Los TORC1 y TORC2 de los mamíferos juegan un papel crítico en la regulación celular.
- La orientación de la TOR de los mamíferos, en particular la TORC1, es prometedora para la intervención terapéutica.
- Los inhibidores de mTOR pueden ofrecer nuevas estrategias de tratamiento para el cáncer, las enfermedades cardiovasculares, la autoinmunidad y los trastornos metabólicos.
Videos de Conceptos Relacionados
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
01:22PI3K/mTOR/AKT Signaling Pathway
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...
01:16TGF - β Signaling Pathway
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:26Signal Transduction: Overview
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...