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Las subunidades auxiliares ayudan a los receptores de glutamato del tipo AMPA
Roger A Nicoll1, Susumu Tomita, David S Bredt
1Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA. nicoll@cmp.ucsf.edu
Science (New York, N.Y.)
|March 4, 2006
Resumen
Las proteínas reguladoras del receptor AMPA transmembrana (TARP) son subunidades auxiliares cruciales que controlan el tráfico y el bloqueo de los receptores de ácido alfa-amino-3-hidroxi-5-metil-4-isoxazolpropiónico (AMPA), lo que afecta el almacenamiento de información en el cerebro.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología molecular y celular Biología molecular y celular.
Sus antecedentes:
- El glutamato es el principal neurotransmisor excitatorio en el cerebro.
- Los receptores ionotrópicos del glutamato incluyen los receptores AMPA y NMDA.
- Los números de los receptores sinápticos de AMPA están implicados en el almacenamiento de información.
Objetivo del estudio:
- Revisar la función de los TARP en la biología de los receptores AMPA.
- Para resaltar los TARP como las primeras subunidades auxiliares identificadas de los receptores ionotrópicos.
Principales métodos:
- Revisión de la literatura de estudios recientes sobre las TARP y los receptores AMPA.
Principales resultados:
- Los TARP regulan tanto el tráfico de receptores AMPA como el encierro de canales.
- Los TARP son esenciales para el ciclo de vida del receptor de AMPA.
Conclusiones:
- Los TARP juegan un papel fundamental en la función del receptor AMPA.
- La comprensión de los TARP es clave para comprender la plasticidad sináptica y el almacenamiento de información.
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