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Síntesis de la plantilla de 1,4,7-trifosfaciclononanes y sus derivados
Peter G Edwards1, Robert Haigh, Dongmei Li
1School of Chemistry, Cardiff University, Main Building, Cardiff CF10 3AT, United Kingdom. edwardspg@cardiff.ac.uk
Journal of the American Chemical Society
|March 16, 2006
Resumen
Este estudio demuestra una nueva síntesis con plantilla de hierro de los derivados trifosfaciclononananos. El método permite la funcionalización controlada y la caracterización de estos importantes macrociclos que contienen fósforo.
Área de la Ciencia:
- Química organometálica Química orgánica de los metales.
- Coordinación Química de la Coordinación
- Química sintética de la química sintética.
Sus antecedentes:
- Los complejos de hierro (II) sirven como plantillas efectivas para la síntesis del macrociclo.
- Las trifosfaciclononanas son ligandos versátiles con aplicaciones en catálisis y ciencia de materiales.
Objetivo del estudio:
- Desarrollar una nueva ruta sintética para los derivados de 1,4,7-trifosfaciclonanano utilizando plantillas de hierro.
- Investigar la influencia de los sustituyentes en la tasa de macrociclación.
- Para explorar la funcionalización de las trifosfaciclononas sintetizadas.
Principales métodos:
- Adición de tipo Michael catalizada por bases de difosfinas y monofosfinas a las vinilfosfinas dentro de complejos de hierro.
- Hidrogenación de grupos vinílicos a grupos etílicos.
- Funcionalización de los donantes secundarios de fosfina a través de la alquilación.
- Caracterización mediante métodos espectroscópicos y cristalografía de rayos X.
Principales resultados:
- Síntesis exitosa de varios derivados de 1,4,7-trifosfaciclonanano coordinados a una plantilla de hierro.
- Se ha demostrado la dependencia de las tasas de macrociclación de los sustituyentes del ligando ciclopentadienil.
- Se logró una mayor funcionalización para producir triterciario-trifosfaciclononas.
- Caracterizó los principales intermediarios y productos a través de la difracción de rayos X.
Conclusiones:
- La plantilla de hierro proporciona una estrategia eficiente para la síntesis de trifosfaciclononas funcionalizadas.
- La metodología sintética permite la introducción controlada de sustitutos y otras modificaciones.
- El estudio pone de relieve la versatilidad de estos macrociclos con plantilla de hierro.
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