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alphaE-catenin controla el tamaño de la corteza cerebral mediante la regulación de la vía de señalización del erizo

Wen-Hui Lien1, Olga Klezovitch, Tania E Fernandez

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Science (New York, N.Y.)
|March 18, 2006
PubMed
Resumen

La deleción de alfa-E-catenina en el sistema nervioso central activa la vía del erizo, lo que lleva al crecimiento excesivo del cerebro. Esto sugiere que la alfaE-catenina normalmente regula el tamaño del cerebro a través de un circuito de retroalimentación negativa.

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