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Videos de Conceptos Relacionados

Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Video Experimental Relacionado

Updated: Jul 9, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

¿El complejo KEOPS: una piedra de roseta para la regulación de los telómeros?

Alessandro Bianchi1, David Shore

  • 1Department of Molecular Biology and NCCR Program "Frontiers in Genetics," University of Geneva, Sciences III, 30, Quai Ernest-Ansermet, CH-1211, Geneva 4, Switzerland.

Cell
|March 28, 2006
PubMed
Resumen

Un complejo recién descubierto, KEOPS, promueve sorprendentemente tanto el desencapado como el alargamiento de los telómeros, arrojando luz sobre los mecanismos de mantenimiento de los telómeros. Este hallazgo avanza en nuestra comprensión de la biología de los telómeros y su relación con la actividad de la telomerasa.

Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • Genética La genética.
  • Biología celular Biología celular.

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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Sus antecedentes:

  • El encapsulamiento de los telómeros y la actividad de la telomerasa son cruciales para la estabilidad genómica, pero sus mecanismos detallados siguen siendo incompletamente comprendidos.
  • Numerosas proteínas han sido implicadas en el encapsulamiento de los telómeros y la función de la telomerasa, sin embargo, falta una imagen completa.