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Cell Size

Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.Surface AreaCells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding the cells limits the...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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Animal and Plant Cell Structure

Animal and plant cells not only differ in their structure, function, and mode of nutrition but also in how they reproduce, specialize, and organize into complex structures.
Cell Division
Though both plant and animal cells divide by mitosis (for non-gametic cells) and meiosis (for gametic cells), they differ in the specifics of this process. Unlike animal cells, plant cells lack centrosomes — an organelle responsible for organizing the spindle fibers and segregating the chromosomes during cell...
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Subcellular Fractionation

The homogenate obtained after cell lysis contains various membrane-bound organelles that can be further separated into pure fractions by subcellular fractionation. These isolates are used to study specific cellular components, analyze localized protein activity, and are even employed in diagnostics. Fractionation is typically achieved using centrifugation methods, the most common being density-gradient and differential centrifugation.
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Cell Inclusions

Prokaryotic cells possess a variety of inclusions that play crucial roles in nutrient storage, metabolic processes, and environmental adaptation. These structures enable bacteria to thrive under fluctuating environmental conditions by storing essential resources and optimizing their metabolic efficiency.Carbon Storage: Poly-β-Hydroxybutyric Acid and Glycogen GranulesBacteria frequently store excess carbon in specialized granules. Poly-β-hydroxybutyric acid (PHB) granules are lipid polymers that...

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Updated: Jul 8, 2026

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
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Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

Las células madre y sus nichos.

Kateri A Moore1, Ihor R Lemischka

  • 1Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, NJ 08544, USA. kamoore@princeton.edu

Science (New York, N.Y.)
|April 1, 2006
PubMed
Resumen

Los nichos de células madre coordinan la autorrenovación y la diferenciación para la producción continua de células. Esta revisión destaca el progreso y las preguntas en los sistemas de células madre intestinales, epidérmicas y de médula ósea.

Área de la Ciencia:

  • Biología de las células madre Biología de las células madre
  • Mecanismos celulares de las células.
  • La homeostasis de los tejidos.

Sus antecedentes:

  • Los mecanismos celulares intrínsecos y extrínsecos regulan la autorrenovación y la diferenciación de las células madre.
  • Las células madre, la progenie y el microambiente forman estructuras anatómicas para la producción celular.
  • La producción continua de células maduras es vital para la vida adulta.

Objetivo del estudio:

  • Discutir el concepto de nicho de las células madre.
  • Resaltar los avances recientes en la investigación de células madre.
  • Identificar las preguntas clave sin respuesta en el campo.

Principales métodos:

  • Revisión de la literatura existente sobre nichos de células madre.

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  • Centrarse en tres sistemas de células madre de mamíferos: epitelio intestinal, epidermis y médula ósea.
  • Análisis de los mecanismos celulares que rigen el comportamiento de las células madre.

    • Principales resultados:

    • Los nichos de células madre son cruciales para coordinar la producción celular.
    • Se han logrado avances significativos en la comprensión de la regulación de nicho.
    • Quedan varias preguntas importantes con respecto a la función y regulación de las células madre.

    Conclusiones:

    • El nicho de las células madre es un concepto fundamental para comprender la regeneración de los tejidos.
    • Se necesita más investigación para dilucidar completamente la complejidad de los nichos de células madre.
    • Comprender estos sistemas es fundamental para la medicina regenerativa y el tratamiento de enfermedades.