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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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La evolución darwiniana puede seguir muy pocas vías mutacionales para adaptarse a las proteínas

Daniel M Weinreich1, Nigel F Delaney, Mark A Depristo

  • 1Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. dmw@post.harvard.edu

Science (New York, N.Y.)
|April 8, 2006
PubMed
Resumen

Las vías evolutivas hacia una alta resistencia a los antibióticos en las bacterias están altamente restringidas. La mayoría de las combinaciones de mutaciones son inaccesibles debido a la pleiotropía, lo que hace que la evolución de las proteínas sea predecible.

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