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El Toxoplasma gondii secuestra los lisosomas de los mamíferos huéspedes en el espacio vacuolar
Isabelle Coppens1, Joe Dan Dunn, Julia D Romano
1Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. icoppens@jhsph.edu
Cell
|April 25, 2006
Resumen
Toxoplasma gondii recluta activamente a los microtúbulos de las células huésped para atraer a los endo-lisosomas a su vacío protector. Este proceso proporciona nutrientes para el crecimiento de los parásitos y secuestra los orgánulos del huésped.
Área de la Ciencia:
- Biología celular Biología celular.
- Parasitología Parasitología.
- Biología molecular La biología molecular.
Sus antecedentes:
- Toxoplasma gondii es un parásito intracelular obligado que se replica dentro de una vacuola derivada del huésped.
- El rápido crecimiento del parásito requiere una eficiente adquisición de nutrientes de la célula huésped.
Objetivo del estudio:
- Aclarar el mecanismo por el cual Toxoplasma gondii adquiere nutrientes del sistema endo-lisosomal del huésped.
- Investigar el papel de la infraestructura celular huésped en el apoyo a la supervivencia intracelular del parásito.
Principales métodos:
- Imágenes de células vivas para observar el tráfico de orgánulos.
- Microscopía de inmunofluorescencia para visualizar la localización de proteínas.
- La manipulación genética de los parásitos y los factores del huésped.
Principales resultados:
- T. gondii recluta activamente los microtúbulos del huésped a la vacuola parasitofórica (PV).
- Los endo-lisosomas del huésped se atraen selectivamente y se entregan a la PV a través de invaginaciones dependientes de los microtúbulos.
- La proteína del parásito GRA7 recubre los conductos tubulares, secuestrando los orgánulos del huésped dentro de la PV.
Conclusiones:
- T. gondii emplea un mecanismo único para secuestrar el tráfico endo-lisosomal del huésped para la adquisición de nutrientes.
- La membrana fotovoltaica forma conductos especializados para el transporte y secuestro unidireccional de orgánulos.
- Este proceso proporciona al parásito acceso concentrado a nutrientes derivados del huésped esenciales para la replicación.
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