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Estructura detallada de las nanopartículas cúbicas lipídicas de tipo diamante
Borislav Angelov1, Angelina Angelova, Brigitte Papahadjopoulos-Sternberg
1Institute of Biophysics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl.21, BG-1113 Sofia, Bulgaria.
Journal of the American Chemical Society
|April 28, 2006
Resumen
Los investigadores crearon nuevas nanopartículas de proteínas / lípidos llamadas cubosomas. Estos cubosomas estables de tipo diamante pueden ser bloques de construcción para sistemas avanzados de administración de fármacos fluidos nanoestructurados.
Área de la Ciencia:
- Se trata de una química supramolecular.
- Nanotecnología La nanotecnología es la nanotecnología.
- Ciencia de los materiales ciencia de los materiales.
Sus antecedentes:
- Los lípidos no lamelares y los fragmentos de proteínas se autoensamblan en estructuras complejas.
- Los cubosomas son nanopartículas con fases cúbicas bicontinuas y canales de agua abierta.
Objetivo del estudio:
- Para caracterizar la estructura de las nanopartículas cúbicas de tipo diamante formadas por el autoensamblaje de proteínas/lípidos.
- Para modelar estas nanopartículas matemáticamente y explorar sus mecanismos de crecimiento.
- Para identificar el bloque de construcción cubosómico estable más pequeño para vehículos de administración de fármacos nanoestructurados.
Principales métodos:
- El autoensamblaje supramolecular de lípidos no lamelares y fragmentos de inmunoglobulina.
- Microscopía electrónica de congelación y fractura para la caracterización estructural.
- Modelado matemático que utiliza superficies nodales para describir las interfaces.
Principales resultados:
- Formación de nanopartículas cúbicas estables de tipo diamante (cubosomas) con interfaces de tipo fluido.
- Identificación de enfoques de aumento y disminución de escala para el crecimiento de nanopartículas.
- Descubrimiento de la más pequeña entidad cubosómica estable de tipo diamante.
Conclusiones:
- Los cubosomas de proteínas/lípidos representan un nuevo bloque de construcción para las nanoestructuras jerárquicas.
- Estos cubosomas muestran potencial para vehículos avanzados de administración de fármacos fluidos nanoestructurados.
- Las ondulaciones lipid-bilayer en los cubosomas pueden afectar su aplicación en la administración de fármacos.
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