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La transformación del factor de crecimiento-beta induce el desarrollo del linaje T(H) 17

Paul R Mangan1, Laurie E Harrington, Darrell B O'Quinn

  • 1Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170, USA.

Nature
|May 2, 2006
PubMed
Resumen

La transformación del factor de crecimiento beta (TGF-β) es crucial para el desarrollo de las células T-helper-17 (T(H) 17 mediante la regulación al alza de la IL-23R. Esta vía de señalización de citoquinas es clave para la inmunidad adaptativa contra las bacterias extracelulares y está implicada en trastornos autoinmunes.

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