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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Recíprocas vías de desarrollo para la generación del efector patogénico TH17 y las células T reguladoras

Estelle Bettelli1, Yijun Carrier, Wenda Gao

  • 1Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Nature
|May 2, 2006
PubMed
Resumen

La interleucina-6 (IL-6) bloquea el desarrollo de las células T reguladoras (Treg) mientras promueve las células T ayudantes 17 (Th17) patógenas. Esta actividad de la IL-6 crea un equilibrio que favorece la lesión del tejido autoinmune sobre su inhibición.

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