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1Department of Clinical Pharmacology and Therapeutics, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
Lancet (London, England)
|February 9, 1991
Resumen
Muchas dosis de medicamentos son innecesariamente altas debido a la comercialización y una preferencia por los números redondos, lo que potencialmente causa efectos secundarios evitables. Se necesitan métodos rigurosos para determinar las dosis y formulaciones óptimas de medicamentos.
Área de la Ciencia:
- Farmacología Farmacología.
- Desarrollo de Drogas Desarrollo de Drogas.
- Ciencias Farmacéuticas Ciencias Farmacéuticas
Sus antecedentes:
- Las dosis recomendadas de medicamentos a menudo exceden las necesidades terapéuticas.
- Los factores que influyen en la selección de la dosis incluyen estrategias de penetración en el mercado y preferencias numéricas.
Objetivo del estudio:
- Para investigar las razones detrás de las dosis innecesariamente altas de drogas.
- Para resaltar el impacto del exceso de dosis en la seguridad del paciente y la eficacia del tratamiento.
Principales métodos:
- Análisis de los factores que influyen en las recomendaciones de dosis de fármacos.
- Evaluación del impacto de la comercialización y las preferencias numéricas en la dosificación.
Principales resultados:
- Las dosis de drogas con frecuencia se fijan más altas para lograr una mayor penetración en el mercado.
- Una preferencia por los números redondos puede conducir a un exceso de dosis, en promedio un 25% y hasta un 70% más alto de lo necesario.
- Las dosis altas aumentan el riesgo de reacciones adversas evitables al medicamento.
Conclusiones:
- Las actuales estrategias de dosificación de fármacos requieren una reevaluación.
- La implementación de métodos científicos rigurosos es esencial para determinar dosis precisas y seguras de fármacos.
- Minimizar el exceso de dosis puede mejorar los resultados de los pacientes y reducir las cargas de atención médica.
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