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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Published on: December 15, 2011

Hidrocortisona: un importante alérgeno cutáneo.

S M Wilkinson1, P H Cartwright, J S English

  • 1Department of Dermatology, North Staffordshire Hospital Centre, Stoke-on-Trent, UK.

Lancet (London, England)
|March 30, 1991
PubMed
Resumen

Un significativo 4,8% de los pacientes con sospecha de dermatitis alérgica de contacto mostraron una alergia a la hidrocortisona. Considere la alergia a la hidrocortisona si las condiciones no mejoran o empeoran después del tratamiento.

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Área de la Ciencia:

  • Dermatología Dermatología dermatología.
  • Alergología Alergología.
  • La medicina clínica es la medicina clínica.

Sus antecedentes:

  • La dermatitis alérgica de contacto es una afección común de la piel.
  • La hidrocortisona es un corticosteroide tópico ampliamente utilizado para enfermedades inflamatorias de la piel.

Objetivo del estudio:

  • Para determinar la incidencia de la alergia a la hidrocortisona en pacientes con sospecha de dermatitis alérgica de contacto.
  • Para resaltar la importancia de considerar la alergia a la hidrocortisona en los casos de no respuesta o empeoramiento.

Principales métodos:

  • Población de pacientes: personas con sospecha de dermatitis alérgica de contacto.
  • Enfoque diagnóstico: evaluación clínica y evaluación de la respuesta a la administración de hidrocortisona.

Principales resultados:

  • Se identificó una alta incidencia del 4,8% para la alergia a la hidrocortisona.
  • Esta alergia se observó en pacientes con sospecha de dermatitis alérgica de contacto.

Conclusiones:

  • La alergia a la hidrocortisona es una preocupación notable en pacientes con sospecha de dermatitis alérgica de contacto.
  • Los médicos deben considerar la alergia a la hidrocortisona cuando una condición no mejora o se deteriora después del tratamiento con hidrocortisona.