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Anormalidades severas en las extremidades después de la toma de muestras de vellosidades coriónicas a los 56-66 días
H V Firth1, P A Boyd, P Chamberlain
1Department of Medical Genetics, Churchill Hospital, Oxford, UK.
Lancet (London, England)
|March 30, 1991
Resumen
El muestreo de vellosidades coriónicas (CVS) durante el embarazo temprano puede estar relacionado con anormalidades severas de las extremidades en los recién nacidos. Se necesita más investigación para confirmar si el CVS es la causa de estos defectos de desarrollo.
Área de la Ciencia:
- Genética médica La genética médica.
- Diagnóstico prenatal y diagnóstico prenatal.
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- El muestreo de vellosidad coriónica (CVS) es un procedimiento de diagnóstico prenatal común.
- Las anomalías de los miembros de aparición temprana son condiciones congénitas graves.
Objetivo del estudio:
- Para investigar una posible asociación entre el muestreo de vellosidades coriónicas (CVS) y las anormalidades severas de las extremidades.
- Evaluar la incidencia de los síndromes de hipogénesis de las extremidades oromandibulares y los defectos de reducción transversa de las extremidades tras el CVS.
Principales métodos:
- Análisis retrospectivo de 289 embarazos sometidos a CVS entre los 56 y 66 días de gestación.
- Identificación y clasificación de anormalidades severas de las extremidades en la descendencia.
Principales resultados:
- Se identificaron cinco casos de anormalidades severas de las extremidades entre 289 embarazos diagnosticados con CVS.
- Cuatro niños presentaron síndromes de hipogénesis de las extremidades oromandibulares.
- Un bebé tenía un defecto terminal en la reducción transversal de las extremidades.
Conclusiones:
- Se observó una mayor incidencia de anormalidades severas en las extremidades que la esperada después de la CVS.
- Los hallazgos sugieren un posible papel etiológico de la CVS en estas anomalías del desarrollo.
- Se requiere una investigación adicional para confirmar la relación causal entre el CVS y las malformaciones de las extremidades.
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