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Deterioro de la memoria al día siguiente con el uso de triazolam
E O Bixler1, A Kales, R L Manfredi
1Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey 17033.
Lancet (London, England)
|April 6, 1991
Resumen
El triazolam, un sedante-hipnótico, con frecuencia causaba deterioro de la memoria al día siguiente y amnesia en los usuarios. El temazepam y el placebo no mostraron estos déficits de memoria significativos, lo que indica que el triazolam
Área de la Ciencia:
- Farmacología Farmacología.
- La neurociencia es la neurociencia.
- Psicología Cognitiva Psicología cognitiva.
Sus antecedentes:
- Las benzodiazepinas se recetan comúnmente para el insomnio.
- Comprender los efectos secundarios cognitivos de las benzodiazepinas de acción corta es crucial para la seguridad del paciente.
- El triazolam y el temazepam son ambas benzodiazepinas de acción corta con diferentes perfiles farmacocinéticos.
Objetivo del estudio:
- Para evaluar la prevalencia, tasa y grado de deterioro de la memoria al día siguiente después de la administración de triazolam, temazepam y placebo antes de acostarse.
- Para comparar los efectos perjudiciales para la memoria del triazolam frente al temazepam y el placebo.
- Investigar la relación entre el consumo de drogas y la aparición de déficits de memoria.
Principales métodos:
- Se empleó un diseño de estudio doble ciego en grupos paralelos.
- Los participantes recibieron triazolam, temazepam o placebo como dosis antes de acostarse.
- Se evaluó la memoria del día siguiente para las actividades y el recuerdo inmediato/retrasado.
Principales resultados:
- 5 de 6 sujetos en el grupo de triazolam reportaron deterioro de la memoria / amnesia al día siguiente (tasa del 40%).
- No se reportaron episodios de deterioro de la memoria en los grupos de temazepam o placebo.
- El deterioro del retraso en el recuerdo fue significativamente mayor con triazolam en comparación con temazepam o placebo.
Conclusiones:
- El triazolam se asocia con una alta incidencia de deterioro de la memoria / amnesia al día siguiente.
- Los deterioros cognitivos por el triazolam pueden representar un espectro de disfunción cerebral orgánica.
- Temazepam no demostró un deterioro significativo de la memoria al día siguiente en este estudio.
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