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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
La prevalencia y la incidencia de la distrofia muscular de Becker
K M Bushby1, M Thambyayah, D Gardner-Medwin
1Department of Neurobiology and Genetics, University of Newcastle upon Tyne, UK.
Lancet (London, England)
|April 27, 1991
Resumen
La distrofia muscular de Becker (DMB) es más común de lo que se pensaba anteriormente, con una prevalencia de 2,38/100,000 en Inglaterra. Su incidencia al nacer es aproximadamente un tercio de la de la distrofia muscular de Duchenne (DMD).
Área de la Ciencia:
- Neurología Neurología.
- Genética La genética.
- Epidemiología La epidemiología.
Sus antecedentes:
- La distrofia muscular de Becker (DMB) es un raro trastorno neuromuscular genético.
- Es posible que las estimaciones anteriores de la prevalencia e incidencia de DMO no reflejen completamente su ocurrencia.
Objetivo del estudio:
- Para determinar la prevalencia y la incidencia de la distrofia muscular de Becker (DMB) en la Región de Salud del Norte de Inglaterra.
- Para comparar la epidemiología de la DMO con la de la distrofia muscular de Duchenne (DMD).
Principales métodos:
- Identificación del paciente a través de registros neurológicos y de laboratorio regionales, y alcance médico.
- Confirmación del diagnóstico utilizando sondas de ADNc y/o inmunolabelamiento con distrofina de muestras de biopsia muscular.
- Comparación de datos epidemiológicos entre DMO y DMD.
Principales resultados:
- Se identificaron 73 pacientes vivos con DMO en la región, lo que da una prevalencia de 2,38 por cada 100.000 habitantes.
- La prevalencia de la DMO es comparable a la de la distrofia muscular de Duchenne (DMD) en 2.48 por cada 100.000.
- La incidencia de nacimientos acumulados por DMO (1 de cada 18.450 nacimientos de varones) es aproximadamente un tercio de la DMO (1 de cada 5.618 nacimientos de varones).
Conclusiones:
- La distrofia muscular de Becker (DMB) parece ser más común de lo que se estimaba anteriormente.
- Los hallazgos sugieren una subestimación significativa del impacto de la DMO en la salud pública.
- Se necesitan más estudios epidemiológicos para confirmar estos hallazgos en poblaciones más amplias.
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