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La anfotericina B liposómica en la leishmaniasis visceral resistente a los fármacos
R N Davidson1, S L Croft, A Scott
1Hospital for Tropical Diseases, London, UK.
Lancet (London, England)
|May 4, 1991
Resumen
La anfotericina B liposómica (L-AmB) ofrece un tratamiento prometedor para la leishmaniasis visceral (VL) resistente a los medicamentos. Esta formulación demostró éxito en un paciente, mostrando una toxicidad reducida en comparación con la anfotericina B (AmB) convencional.
Área de la Ciencia:
- Enfermedades infecciosas Enfermedades infecciosas.
- Farmacología Farmacología.
- Sistemas de suministro de drogas Sistemas de suministro de drogas.
Sus antecedentes:
- El tratamiento de la leishmaniasis visceral (VL) se enfrenta a desafíos debido a la toxicidad y resistencia a los medicamentos.
- La anfotericina B (AmB) convencional es efectiva, pero causa efectos secundarios significativos como insuficiencia renal y anemia.
- La administración de fármacos liposomales tiene como objetivo atacar los macrófagos infectados, mejorando la eficacia y reduciendo la toxicidad.
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