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Updated: May 8, 2026
08:45
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
Una fosfatasa controla el destino de los Smads regulados por el receptor
Stephen H Schilling1, Michael B Datto, Xiao-Fan Wang
1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Cell
|June 6, 2006
Resumen
Los investigadores identificaron PPM1A, una fosfatasa que limita la activación de Smad2 y Smad3 mediante su desfosforilación. Este hallazgo aborda una pregunta clave en la vía de señalización del factor de crecimiento transformador-beta (TGFbeta).
Área de la Ciencia:
- Biología Molecular Biología Molecular
- La señalización celular de las células.
- La bioquímica es la bioquímica.
Sus antecedentes:
- La vía de señalización del factor de crecimiento transformador-beta (TGFbeta) juega un papel crucial en los procesos celulares como la proliferación, la diferenciación y la apoptosis.
- La activación de las proteínas Smad2 y Smad3 es un evento central en la señalización de TGFbeta, pero los mecanismos que limitan esta activación no se han entendido completamente.
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