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Administración de péptido antidiurético (DDAVP) por succión de piel desepitelizada
P Svedman1, S Lundin, C Svedman
1Department of Plastic and Reconstructive Surgery, University of Lund, Malmö, Sweden.
Lancet (London, England)
|June 22, 1991
Resumen
Un nuevo método de administración transdérmica de fármacos, que implica la eliminación indolora de la epidermis, logró el 100% de biodisponibilidad para la 1-deamino-8-D-arginina vasopresina (DDAVP). Esta técnica es prometedora para la absorción efectiva del fármaco, incluso con la aplicación repetida.
Área de la Ciencia:
- Farmacología Farmacología.
- Dermatología Dermatología dermatología.
- Ingeniería Biomédica Ingeniería Biomédica.
Sus antecedentes:
- La epidermis presenta una barrera significativa para la administración transdérmica de fármacos.
- Lograr una absorción completa y predecible del medicamento a través de la piel sigue siendo un desafío.
Objetivo del estudio:
- Evaluar una nueva técnica de administración transdérmica de fármacos que implica la extirpación de la epidermis.
- Para evaluar la biodisponibilidad y la eficacia de la 1-deamino-8-D-arginina vasopresina (DDAVP) utilizando este método.
Principales métodos:
- Una pequeña área de la epidermis del antebrazo (5 mm de diámetro) se extirpó sin dolor utilizando un dispositivo de vacío.
- DDAVP se administró a través de reservorios oclusivos aplicados en el sitio desepitelizado.
- Las concentraciones plasmáticas de DDAVP se monitorearon a lo largo del tiempo utilizando medición de flujo doppler láser.
Principales resultados:
- Las concentraciones plasmáticas de DDAVP siguieron una cinética de orden cero, lo que indica una biodisponibilidad cercana al 100%, comparable a la infusión intravenosa.
- La administración diaria repetida durante 4 días no mostró ningún obstáculo para la reepitelización de la piel.
- Los niveles plasmáticos alcanzados de DDAVP excedieron las concentraciones terapéuticas para la diabetes insipida.
Conclusiones:
- La eliminación indolora de la epidermis asistida por vacío es un método eficaz para la administración transdérmica de fármacos.
- Esta técnica ofrece una alta biodisponibilidad y potencial terapéutico para fármacos como el DDAVP.
- La hiperemia dérmica inducida puede mejorar la permeación del fármaco, con la piel volviendo a la normalidad en 6 semanas.
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