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Interacciones sociales entre las células epiteliales durante la morfogénesis de ramificación traqueal
Amin S Ghabrial1, Mark A Krasnow
1Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA.
Nature
|June 9, 2006
Resumen
Las células epiteliales coordinan la formación de la red tubular a través de la competencia celular. Las células con alta actividad del receptor del Factor de Crecimiento de Fibroblastos (FGF) lideran la ramificación, mientras que otras siguen, formando tubos en un proceso que implica la inhibición lateral.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología celular Biología celular.
- Genética La genética.
Sus antecedentes:
- El desarrollo de los órganos a menudo implica redes tubulares formadas por morfogénesis ramificada.
- Se sabe que los factores de crecimiento de los fibroblastos (FGF) guían el brote y el crecimiento de las ramas.
- Los mecanismos de coordinación de las células epiteliales durante la formación del tubo siguen sin estar claros.
Objetivo del estudio:
- Para dilucidar cómo las células epiteliales coordinan los movimientos y la morfogénesis durante la formación de tubos.
- Para identificar roles celulares distintos en el brote de las ramas traqueales.
- Investigar los mecanismos moleculares que subyacen a la coordinación celular en la morfogénesis ramificada.
Principales métodos:
- Se utilizó el análisis de mosaico genético en Drosophila melanogaster.
- Investigó los roles de la señalización del FGF y la actividad del receptor.
- Se examinó la participación de la inhibición lateral mediada por Notch.
Principales resultados:
- Identificó dos clases de células distintas en las ramas traqueales en ciernes: células de punta avanzada y células de tallo final.
- Se demostró que los roles celulares están determinados por la competencia por la actividad del receptor FGF, no por la prespecificación.
- Se demostró que la inhibición lateral mediada por Notch impide que múltiples células tomen posiciones de liderazgo.
Conclusiones:
- La morfogénesis ramificada implica competencia celular, donde la actividad del receptor FGF dicta el destino y la posición de la célula.
- La cooperación entre las células facilita el crecimiento eficiente de las ramas, incluso para las células con una mala respuesta quimioattractante.
- Este estudio revela un nuevo mecanismo para coordinar el comportamiento celular durante la formación de estructuras tubulares.
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