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Importancia de SoxE en el desarrollo de la cresta neural y la evolución de la faringe
David W McCauley1, Marianne Bronner-Fraser
1Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. dwmccauley@ou.edu
Nature
|June 9, 2006
Resumen
El desarrollo de la cresta neural en las lampreas de mar revela funciones conservadas del gen SoxE en la evolución de los vertebrados. Estos genes son cruciales para el desarrollo craneofacial, destacando su antiguo papel en la formación de arcos branquiales.
Área de la Ciencia:
- Biología del desarrollo evolutivo Biología del desarrollo evolutivo
- La genómica comparada es una genómica comparada.
- Paleontología de los vertebrados.
Sus antecedentes:
- La cresta neural es una innovación de los vertebrados crucial para el desarrollo craneofacial.
- Los genes SoxE (Sox8, Sox9, Sox10) son reguladores clave del desarrollo de la cresta neural en los vertebrados con mandíbula.
- Comprender la función SoxE en los vertebrados basales ilumina la evolución de la cresta neural.
Objetivo del estudio:
- Investigar el papel de los genes SoxE en el desarrollo craneofacial de la lamprea marina (Petromyzon marinus).
- Rastrear los orígenes evolutivos de la función del gen SoxE en el desarrollo del arco branquial de los vertebrados.
Principales métodos:
- Se analizaron los patrones de expresión de los genes SoxE en embriones de lampreas marinas.
- Utilizó el knockdown de genes mediado por Morpholino para evaluar la función de SoxE1.
- Examinó el desarrollo del arco craneofacial y branquial.
Principales resultados:
- Dos genes SoxE de la lamprea marina se expresan en la migración de la cresta neural y el desarrollo de arcos branquiales.
- SoxE1 knockdown interrumpe el desarrollo del arco branquial posterior pero no el desarrollo del arco mandibular.
- Los genes SoxE juegan un papel esencial en la condrogénesis dentro de los arcos branquiales.
Conclusiones:
- La función condrogénica de los reguladores SoxE se conserva desde el antepasado común de la lamprea-gnatostoma.
- Los genes Lamprey SoxE pueden haber sufrido duplicaciones independientes, lo que lleva a funciones especializadas.
- Este estudio proporciona información sobre la homología de los arcos branquiales de los vertebrados y sus orígenes evolutivos.
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