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In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
Efecto de las bajas concentraciones de ozono en las respuestas alérgicas inhaladas en sujetos asmáticos
N A Molfino1, S C Wright, I Katz
1Department of Medicine, University of Toronto, Ontario, Canada.
Lancet (London, England)
|July 27, 1991
Resumen
La exposición a bajos niveles de ozono aumenta significativamente la capacidad de respuesta de las vías respiratorias a los alérgenos en personas con asma. Este efecto del ozono en los síntomas de asma no altera la función pulmonar basal.
Área de la Ciencia:
- Salud Ambiental Salud del medio ambiente.
- Medicina Pulmonar La medicina pulmonar es el tratamiento de las enfermedades pulmonares.
- Alergia Inmunología de la alergia.
Sus antecedentes:
- El ozono y los alérgenos pueden causar inflamación de las vías respiratorias, lo que podría afectar al asma.
- Comprender la interacción entre el ozono ambiental y las respuestas alérgicas es crucial para el manejo del asma.
Objetivo del estudio:
- Investigar si la exposición a niveles bajos de ozono potencia la respuesta alérgica de las vías respiratorias en pacientes asmáticos.
- Para determinar si el ozono afecta la respuesta bronquial a los alérgenos inhalados.
Principales métodos:
- Siete pacientes asmáticos atópicos se sometieron a desafíos de metacolina y pruebas de inhalación de alérgenos.
- Los sujetos fueron expuestos al aire o al ozono 0.12 ppm durante 1 hora antes de la inhalación de alérgenos o placebo.
- La capacidad de respuesta de las vías respiratorias se midió por la concentración de alérgeno requerida para causar una caída del 15% en FEV1 (PC15).
Principales resultados:
- La exposición al ozono no alteró significativamente el volumen expiratorio forzado basal en 1 segundo (FEV1).
- La PC15 se redujo significativamente después de la inhalación de ozono seguido de alérgeno, lo que indica una mayor capacidad de respuesta (media de PC15: 0.0056 mg / ml después de la ozona frente a 0.013 mg / ml después del aire).
Conclusiones:
- La exposición a un bajo nivel de ozono, común en las zonas urbanas, mejora la respuesta bronquial a los alérgenos en los asmáticos atópicos.
- Esta potenciación de la respuesta alérgica por el ozono ocurre sin cambios en la función de las vías respiratorias basal.
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